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<p><span class=SpellE><span style='font-family:Arial;color:black'>Injectable</span></span><span
style='font-family:Arial;color:black'> Vitamin C: Additional Information </span><b
style='mso-bidi-font-weight:normal'><span style='font-family:Arial'><o:p></o:p></span></b></p>
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<p><span style='color:red'>Vitamin C for Injection<o:p></o:p></span></p>
<p><span style='color:red'><span style='mso-spacerun:yes'>�</span></span><br>
<a href="index.html">Home</a></p>
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<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>Dr Steve Hickey�s
Comments on <span class=SpellE>Injectable</span> Ascorbic Acid Additives: <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>�Ascorbate
(vitamin C) in solution can combine with metal ions such as iron or copper in
a Fenton reaction. The result is the gradual oxidation of the solution. A
solution of ascorbate in water will discolor with time as the oxidation
progresses. Use of distilled water can lower the concentration of free metal
ions and slow the oxidation of ascorbate. However, practically there are
still metal ions present to promote oxidation.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'> <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>�A
chelation agent will bind free metal ions and prevent them from reacting with
the ascorbate in solution. Both EDTA and calcium gluconate can act as
chelation agents. EDTA is the better-known <span class=SpellE>chelator</span>.
Here is a data page for calcium gluconate: <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-family:Arial'> <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:9.0pt;font-family:Arial'><a
href="http://chemicalland21.com/lifescience/UH/CALCIUM%20GLUCONATE.htm">http://chemicalland21.com/lifescience/UH/CALCIUM%20GLUCONATE.htm</a><o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:9.0pt;font-family:Arial'><br>
�</span><span style='font-size:11.0pt;font-family:Arial'>This next paper
explains how calcium gluconate may be a poor donor of calcium ions because of
its chelating properties. (It binds the calcium quite tightly.)<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'> <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:Arial'><a
href="http://emj.bmj.com/cgi/content/extract/19/1/92-a">http://emj.bmj.com/cgi/content/extract/19/1/92-a</a><o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'> <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>�The use
of both substances is consistent with their action as chelating agents. Since
their concentrations would be expected to be low in the solution, which is
used may simply be a matter of the physician�s choice.�<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:11.0pt;font-family:Arial'>For more information on
intravenous vitamin C:<o:p></o:p></span></b></p>
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