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| author | luxagraf <sng@luxagraf.net> | 2020-11-29 13:17:50 -0500 |
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| committer | luxagraf <sng@luxagraf.net> | 2020-11-29 13:17:50 -0500 |
| commit | 642b5821695f286c6e2510c45a33e16eec249d65 (patch) | |
| tree | 317f03ca88e34d5fd68514bcad406b89f7207d5e /reference/www.doctoryourself.com/fluoride_cancer.html | |
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To what extent is science ruled by politics?"> +<meta name=KeyWords +content="Peter Meiers, fluoride, fluoridation, York, cancer, National Health Service, NHS, National Cancer Institute, NCI, American Dental Association, ADA, dentist, teeth"> +<!--[if gte mso 9]><xml> + <o:shapedefaults v:ext="edit" spidmax="2050"/> +</xml><![endif]--><!--[if gte mso 9]><xml> + <o:shapelayout v:ext="edit"> + <o:idmap v:ext="edit" data="1"/> + </o:shapelayout></xml><![endif]--> + +<!-- ADD style1 ===================== --> +<style type="text/css"> +#TFlag +{ + float:right; + font-size:105%; + line-height:105%; + padding:.15 em; + margin:.15 em; +} +img.top +{ + vertical-align:text-top; +} +</style> +<!-- END ADD style1 ===================== --> + +</head> + +<body bgcolor=white background="images/architek0H.gif" lang=EN-US link=blue +vlink=blue style='tab-interval:.5in'> + +<!-- ADD TFlag ===================== --> +<span id ="TFlag"> + <a href="#translator_block"> + Click here to translate this page. + <img class="top" SRC="images/TranslateFlag.jpg" alt="translate gadget at page bottom" height=36> + </a> +</span> +<!-- END ADD TFlag ===================== --> + +<div class=Section1> + +<p class=MsoNormal> </p> + +<table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 + style='mso-cellspacing:0in;mso-padding-alt:0in 0in 0in 0in'> + <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes'> + <td width=132 style='width:99.0pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><img width=117 height=105 id="_x0000_i1025" + src="images/logo1.GIF"></p> + </td> + <td width=16 style='width:12.0pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><o:p> </o:p></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><img width=365 height=60 id="_x0000_i1026" + src="images/dystitle2.JPG"><br> + <img width=365 height=20 id="_x0000_i1027" src="images/dysaut.JPG"></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><b><span style='font-family:Arial'>Fluoridation Side + Effects</span></b></p> + </td> + </tr> +</table> + +<div class=MsoNormal align=center style='text-align:center'> + +<hr size=2 width="100%" align=center> + +</div> + +<table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 + style='mso-cellspacing:0in;mso-padding-alt:0in 0in 0in 0in'> + <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> + <td width=132 valign=top style='width:99.0pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><span style='color:red'>Fluoride, Cancer</span> <br> + <a href="index.html">Home</a></p> + </td> + <td width=18 style='width:13.5pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><o:p> </o:p></p> + </td> + <td valign=top style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><b><span style='font-family:Arial'>Does water fluoridation + have negative side effects?</span></b> <br> + <span style='font-size:11.0pt;font-family:Arial'>A critique of the York + Review</span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Objective 4, Sections + 9.1 to 9.6 : CANCER STUDIES</span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>by Peter Meiers, <st1:place + w:st="on"><st1:City w:st="on">Saarbruecken</st1:City>, <st1:country-region + w:st="on">Germany</st1:country-region></st1:place></span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>(October 30, 2000)</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>(Note by Andrew Saul:<i> + Fluoridation of water owes its continued existence more to politics than to + science. If safety and effectiveness are truly considered, fluoride + would be questionable even as a prescription drug. But to freely add it + to public water supplies, often without any public vote whatsoever, is far + beyond questionable. Mr. Meiers' discussion of the dangers of fluoride + is important reading.)</i></span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>The National Health + Service (NHS) Centre for Reviews and Dissemination at the <st1:place w:st="on"><st1:PlaceType + w:st="on">University</st1:PlaceType> of <st1:PlaceName w:st="on">York</st1:PlaceName></st1:place> + recently released a review perceived to be "the final word on + fluoridation" [McDonagh et al. 2000]. To judge from the course of a + discussion about the layout of this <st1:City w:st="on"><st1:place w:st="on">York</st1:place></st1:City> + review [Schuld 2000], the result was to be expected: benefits (though smaller + than previously claimed) with regard to caries prophylaxis, at the cost of + some "cosmetic defects" (dental fluorosis), no harm to general + health. This report is just one of many made in the past apparently aimed at + giving support to preoccupied views of the proponents of fluoridation. Like + other sections, the evaluation of the fluoridation-cancer link in this report + is far from presenting "a summary of the best available and most + reliable evidence on the safety and efficacy of water fluoridation". Not + only did the <st1:City w:st="on"><st1:place w:st="on">York</st1:place></st1:City> + team disregard all relevant experimental data (a prerequisite to decide what + effects of fluoride should be looked for), it also, quite obvious to anyone + knowing the relevant literature, distorted facts to make its point. </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>This is not a new + experience. Fears of undesired effects of the controversial "public + health measure" have never been taken serious by its promoters. Even + though animal experimentation on fluoride and cancer, performed long before + any fluoridation experiment was started in the United States [Meiers 1984, + 1986], could have given reason for concern, investigations into possible + fluoride effects on human cancer victims were not initiated by promoters of + the measure prior to any fluoridation efforts nor in the course of the first + experimental trials, but by opponents whose charges posed a threat to the + continuing supply of public funds and thus necessitated appropriate replies + [American Dental Association 1952]. For example, at government hearings in + 1952, <st1:City w:st="on"><st1:place w:st="on">Taylor</st1:place></st1:City> + [1952] presented evidence that fluoride shortens the lifespan of cancer-prone + mice. Perkins [1952] speculated on this basis that people in fluoridated + cities might die of cancer at an earlier age because of their fluoride + exposure: If a person would die of cancer at the age of 80, 70, 60, 50, or 40 + on a water intake free from fluorine, the same per-son would die at the age + of 65.6, 57.4, 49.2, 41, or 32.8 years, respectively, on a water intake + containing approximately 1 ppm of sodium fluoride. </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Relative to the city of + Grand Rapids, fluoridated since January 1945, Perkins wrote: </span><span + style='font-size:11.0pt'> <br> + </span><i><span style='font-size:11.0pt;font-family:Arial'>"The vital + statistics provided by the health authorities of that city to the United + States Public Health Service and published in ´Vital Statistics of the United + States´, Part II, Table 14, for the year 1945 (the year fluoridation was + installed in Grand Rapids) show that 252 persons died of cancer. Four years + later, the same sources showed that the deaths in that city from cancer + totaled 349. This is an increase of approximately 39 percent in cancer deaths + during the first five years of fluoridation in <st1:City w:st="on"><st1:place + w:st="on">Grand Rapids</st1:place></st1:City>. It is significant that the + records for the five years previous to the adoption of fluoridation showed an + actual decrease in the cancer death rate of approximately 6 + percent." </span></i><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>It was these claims that + prompted Swanberg [1953] to evaluate the cancer data of <st1:City w:st="on">Grand + Rapids</st1:City> and to compare them with cancer mortality data for the <st1:country-region + w:st="on"><st1:place w:st="on">United States</st1:place></st1:country-region> + as a whole. The York Committee describes this study [Section 9.4] as showing + that "The death rate from cancer in the study area decreased during the + study period whereas the death rate from cancer in the whole of the US (the + control area) increased over the same period" and excludes it from the + main analysis because the "whole of the US includes areas with fluoride + in the water supplies and so [is] not a suitable control area". While + this was a wise decision [see Ziegelbecker 1987] the team did not realize, + apparently, that the Swanberg study actually revealed something quite + different from the author's conclusion: the number of cancer deaths per + 100,000 residents per year increased in <st1:City w:st="on">Grand Rapids</st1:City> + as it did in the <st1:country-region w:st="on"><st1:place w:st="on">U.S.A.</st1:place></st1:country-region> + (Fig.1, upper graph). As to the large rise during the years of World War II + and the decrease afterwards, Swanberg explains that "it is known that in + the early forties there was a migration away from <st1:City w:st="on"><st1:place + w:st="on">Grand Rapids</st1:place></st1:City> toward the center of war + industries. After 1945 there was a migration back" which fact is + illustrated in the lower graph of Fig.1 (data taken from Swanberg´s + publication). If this migration involved just the younger residents it led to + a relative increase of the fraction of older people "per 100,000 + residents" during the years of war, thus increasing the crude cancer + death rate. Though Swanberg, editor of the journal that published his study, + gave the full set of data, he selected for his conclusion those data points + appropriate to show a decrease in cancer death rate after the start of + fluoridation:</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>"The death rate from + cancer in <st1:City w:st="on"><st1:place w:st="on">Grand Rapids</st1:place></st1:City> + in 1944, the year before fluoridation was adopted, is given as 206.2 per + 100,000 population. In 1952, after 8 years of fluoridation, the cancer death + rate was 185.3 per 100,000, a decrease of 10 per cent. In the 9-year period + between 1944 and 1952 in the <st1:country-region w:st="on"><st1:place w:st="on">United + States</st1:place></st1:country-region> as a whole, the cancer death rate + rose from 124 per 100,000 population in 1944 to 143.9 per 100,000 in 1952, an + increase of 16 per cent."</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>The <st1:City w:st="on"><st1:place + w:st="on">York</st1:place></st1:City> review committee either did not + realize this fraud or it chose to mention the unjustified conclusions of the + author to put some undeserved weight to other studies which apparently found + a decrease in cancer death rates after fluoridation started.</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Likewise, the <st1:City + w:st="on"><st1:place w:st="on">York</st1:place></st1:City> team used a very + special approach to evaluate data from the Newburgh-Kingston study by + Schlesinger et al. [1956]. Table 12 in the Schlesinger et al. publication + lists the number of cancer deaths per 100,000 people in fluoridated Newburgh + and the non-fluoridated control city of Kingston for 1942 to 1954, an up and + down so that hardly any difference can be ascertained between the two cities + (Fig. 2). Yet, the York review team [see App. C10, p. 196] excerpted from + this list data for 1944 (219.0 for Newburgh vs. 169.0 for Kingston) and the + last year reported (221.2 for Newburgh, 264.4 for Kingston) when the number + of cancer deaths was in favor of fluoridated Newburgh (while in 1952, for + example, it was lower in Kingston). With this data selection the <st1:City + w:st="on">York</st1:City> team created the picture that cancer mortality went + way up in non-fluoridated <st1:City w:st="on">Kingston</st1:City>, while it + remained nearly unchanged in fluoridated <st1:City w:st="on"><st1:place + w:st="on">Newburgh</st1:place></st1:City>. </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Several studies published + after the 1956 Newburgh-Kingston "final report" focused on possible + effects of natural fluoride waters on the incidence or mortality of cancer + and revealed some major shortcomings. They were essentially static (comparing + data of just one year) as opposed to the time-trend analyses quoted above. + Further-more, the concentration of natural fluoride varies (even in one and + the same water supply), and so does the num-ber of registered water supplies + within each municipality [Heasman and Martin 1962; Glattre and Wiese 1979]. + Therefore, it seems to make no sense to compare areas with a water fluoride + level of 0.06-0.10 mg/l to areas with 0.11-0.5 mg/l, as Glattre and Wiese do, + nor to arrange fluoride cities into groups based on a difference of one + hundredth mg/l (i.e. 0,5-0,99 vs.1 mg/l and more) as Kinlen [1974, + 1975] does. Where more than one water source supplies a local authority some + authors calculated "weighted means" [Chilvers and <st1:City w:st="on"><st1:place + w:st="on">Conway</st1:place></st1:City> 1985]. On this basis, the latter + authors found some of the areas used by Kinlen [1974, 1975] to be + misclassified (see also Heasman and Martin 1962; Nixon and Carpenter 1974). + While these facts should have been reason enough to exclude the Kinlen paper + from the main analysis in the York review, his method of standardization + should have given it the final blow. But as to the Standard population used + by Kinlen the York team claims: "Not stated" (Appendix C10, p. + 191). The Kinlen paper has appendices, among them Appendix B which reads:</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>"The method for + obtaining the ratios shown in table I was to calculate for each sex and each + age group the number of cases that would be expected in the population in + question in each fluoride category if the total number of cases in all areas + combined was distributed uniformly." That means, he pooled the groups to + calculate his "expected" cancer deaths and thus used a reference + population partly exposed to the variable to be tested! While the <st1:City + w:st="on"><st1:place w:st="on">York</st1:place></st1:City> team excluded the + Swanberg study on this basis, it did ignore the same mistake made by + Kinlen. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>In case fluoride + increases the number of deaths, inclusion of exposed people in the reference + population would raise the number of (speculative) "expected" + deaths in the groups to be examined (depending on population structure). As + Standardized Mortality Ratios (SMR´s) are calculated by dividing the number + of observed cancer deaths per 100,000 people (O) by the number of + "expected" cancer deaths per 100,000 people (E), the SMR (O:E) + becomes the lower the higher the "expected" (E) rate. This kind of + SMR calculation applied in time-trend studies to populations of different + size and structure (fluoridated vs. non-fluoridated cities) using a shifting + refer-ence population (USA 1950, 1960, 1970 as the standard for the + corresponding census years) creates the artifact of decreasing cancer death + rates in fluoridated cities. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>An example: In a hypothetical + population with no change both in population structure and the number of + cancer deaths during 1950 to 1970, applying U. S. data in 1950 by age, gender + and race to calculate the number of deaths expected for 1950 in that + population, and likewise U.S. data in 1960 and 1970 for those respective + years, will result in an increasing number of expected deaths in the time + span 1950 to 1970, since cancer death rates rose in the U.S. during that + time. As the number of deaths expected in the hypothetical population will + increase, i.e. "E" becomes higher, the O:E ratio (SMR) becomes + lower. Thus one will be able to show that the cancer death rates decreased in + that population (while, as presupposed above, nothing happened at all with + the actual rates). What a large increase in cancer death rates would be + required just to balance the misleading SMR calcu-lations for the + hypothetical population if it were exposed to a carcinogen to be evaluated!</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>This is why the + re-analyses by Smith [1980] as well as Kinlen and Doll [1981] of the + Yiamouyiannis and Burk [1977] study on the fluoridation-cancer link are + useless. Of these, the Smith paper got a high ranking according to the <st1:City + w:st="on"><st1:place w:st="on">York</st1:place></st1:City> validity checklist + for it "did not include the error in the NCI data" (Section 9.1.1) – + which isn´t true, of course. After all, how can one expect the <st1:City + w:st="on"><st1:place w:st="on">York</st1:place></st1:City> committee members + to know the details of that year-long discussion of the 20-cities study to + evaluate properly the relevance of Smith´s re-analysis?</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>As the Grand Rapids and + Newburgh/Kingston data show, there are large fluctuations of cancer death + rates over time in individual cities so that it isn´t appropriate to select + just two data points for statistical evaluation, but the best approach would + be to make a linear regression analysis to compare rates before and after + fluoridation started. As differences might be small it seems to be a good + idea to pool the data of several fluoridated cities and to compare them to a + set of non-fluoridated ones.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>In 1975, Yiamouyiannis + and Burk reported to the U.S. Congress that a set of 20 U.S. central cities + had almost identical cancer mortality rates (cancer deaths per 100,000 people + per year) between 1940 and 1950, but that since fluoridation started (in + 1952-1956) in a group of ten of these cities their cancer death rate + increased faster than that of the ten cities remaining non-fluoridated (Fig. + 3). The study was later published in the Journal "Fluoride" + [Yiamouyiannis and Burk 1977] and caused quite a stir. </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Early in 1976, a + representative of the National Cancer Institute (NCI) claimed in a letter to + Congressman Delaney that the NCI´s re-analysis showed that the increase was + entirely due to changes in the age, race and sex structure of the population + in question [Fredrickson 1976]. While refusing congressional requests for + detailed data (weighted or unweighted rates used? Which reference population? + etc.), the NCI clandestinely has passed this data on to other scientists + [Yiamouyiannis 1977] who reported them as their "independent analysis" + [Doll and Kinlen 1977; <st1:place w:st="on">Oldham</st1:place> and Newell + 1977]. However, the NCI data submitted contained two characteristic errors + reproduced in both papers: (A) The non-white females, age 65-74 in 1970, in + the non-fluoridated population should be 46.1 (not 51.1; thousands) so that + the total population becomes 7342.7 (thousands) instead of 7347.7. As a + result the expected number of cancer deaths in non-fluoridated cities in 1970 + is 12,384 (instead of 12,407). (B) Total cancer deaths in the non-fluoridated + cities in 1970 should be 14,272 (and not 14,487) [Kinlen and Doll, 1977; <st1:place + w:st="on">Oldham</st1:place> and Newell 1979]. The Smith [1980] paper + eliminated error (B) of the NCI data, but still contains error (A).</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>However, the main point + of disagreement between the statisticians is that whereas Burk and his group + derived putative "observed Cancer Death Rates" (CDRo) by linear + regression analysis of all available and pertinent data, i.e. the crude CDR´s + characterizing the observation period of 1953 to 1968, and extrapolation to + 1950 and 1970, other investigators have taken reported or pericensal CDRo + figures for 1950 and 1970. "If, as they say, only the censal or + pericensal data for 1950 or 1970 ought to be taken into account, the + association between fluoridation and cancer is wiped away by adjustment. If + instead, as we insist, the intermediate data for 1953 through 1968 must be + used, a large association remains, notwithstanding adjustment" [Graham + et al. 1987]. Neither regression analysis of cancer death rates + [Mahoney et al. 1991] nor calculation of intercensal population by + interpolation of data acquired in census years [Cohn 1992] seem to be + unacceptable methods. Furthermore, a look at age-specific cancer mortality + data for the twenty cities, unfortunately only available for 1970, indicates + a higher cancer mor-tality at an earlier age in the fluoridated group (Fig. + 4). The difference is obvious in these large populations even though people + in non-fluoridated cities are exposed to fluoride from sources other than + drinking water (tablets, drops, mouthwashes, topical applications, canned + foods prepared in fluoridated cities, etc.).</span><span style='font-size: + 11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>While epidemiologists + hitherto essentially looked for evidence in human populations of a per se + carcinogenic effect of fluoride, substantiated by more recent in-vitro + experiments [Tsutsui et al. 1984; Jones et al. 1988; Lasne et al. 1988], the + question raised by Perkins in 1952 relative to the promoter effects of + fluorides has still not been addressed, neither by health officials in + general nor by the York team. Humans today are exposed to not one but many + different carcinogenic agents (including chemicals, viruses, ionizing + radiation) which interact in very intri-cate ways. Fluoride is known to + inhibit some enzymes and to activate others. Fluoride inhibits the enzymatic + deacetylation of N-Hydroxy-Acetylaminofluorene [<st1:City w:st="on"><st1:place + w:st="on">Irving</st1:place></st1:City> 1966] and thus leaves more of the + substrate for a sulfotransferase enzyme that builds the ultimate carcinogen + from that compound. Fluoride activation of dimethyl-nitrosamine demethylase + in liver microsomes [Dophuoc et al. 1981, 1983] increases the carcinogenic + potential of dimethylnitrosamine. It has no obvious influence on the + oxidative activation of the ubiquitous carcinogenic hy-drocarbon + benzo(a)pyrene in vitro [Dophuoc et al. 1981, 1983], yet addition of fluoride + to the food of experi-mental animals injected with this compound leads to + increased incidence of malignant tumors [Tannenbaum and Silversone 1949]. + Likewise, skin cancer induced in animals by skin painting with benzo(a)pyrene + becomes ear-lier visible and leads to earlier death if the painting solution + contains 1 ppm fluoride (as sodium fluoride) in ad-dition to the hydrocarbon + [Wagner 1981]. Beryllium compounds are carcinogenic, but exposure of animals + to be-ryllium fluoride enhances the growth of lung tumors induced by the + beryllium [Schepers 1961]. Fluoride and fluorophosphate promote tumor growth + induced in vitro by benzo(a)pyrene and many other compounds [Jones et al. + 1988]. In this assay the promoter effect came to a halt as soon as the + fluoride was omitted from the culture medium. Thus the early experiments of <st1:City + w:st="on"><st1:place w:st="on">Taylor</st1:place></st1:City> [1952, 1954, + 1965] are fully supported by more recent evidence.</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>According to a WHO + scientific group "the occurrence of tumors earlier than in the controls, + without increased incidence" is among the types of responses "used + to classify chemicals as carcinogens" [WHO 1969].</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Enhancing effects are + also apparent from some life table data published in the National Toxicology + Program carcinogenicity test of sodium fluoride [NTP 1990]. This test had + been requested by the U.S. Congress during hearings in 1977. Back then, NCI + representative Kraybill [1977] presented a list of publications which, he + al-leged, had already shown that sodium fluoride has no carcinogenic + activity. However, not a single one of the publications on his list had + anything to do with fluoride and cancer. Anyway, the start of the + carcinogenicity test requested by Congress was announced four years later + [Whitmire 1981]. After another four years, a first result was declared + inadequate because the low fluoride semisynthetic diet "was deficient in + several vitamins and minerals" [NTP 1985]. Another two-year study was + scheduled to begin in October 1985. The report, released in 1990, focused on + the occurrence of a rare form of cancer, osteosarcoma, in several of the male + (but not the fe-male) dosed rats used in the study [NTP 1990]. This evidence + of carcinogenicity was downgraded to be "equivocal".</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Nevertheless, a few + epidemiological studies addressed a possible influence of water fluoridation + on the incidence of osteosarcoma in humans. It occurs in less than one in + 100,000 people or about 0.1 percent of all reported can-cers, and therefore + it would be hard to detect small increases in risk (on the order of five to + ten percent) [USPHS 1991]. Examinations in a very limited number of + afflicted people led to conflicting results. The study designs (e.g. + exclusion of people formerly exposed to some radiation) reveal that still the + search for a per se carcinogenic effect of fluoride was in the foreground. + There seems to be agreement that osteosarcoma incidence in the <st1:country-region + w:st="on"><st1:place w:st="on">U. S.</st1:place></st1:country-region> + increased in people below age 30 with some decrease at later age. A + contribution by water fluoridation could not be ascertained by these limited + studies, but obvious difficulties in classification of exposure to + fluoridated drinking water and examination of exposure from other sources + need to be more carefully addressed in more thorough future investigations. + The <st1:City w:st="on"><st1:place w:st="on">York</st1:place></st1:City> team + apparently was not aware of these shortcomings.</span><span style='font-size: + 11.0pt'> <o:p></o:p></span></p> + <p><b><span style='font-size:11.0pt;font-family:Arial'>In summary</span></b><span + style='font-size:11.0pt;font-family:Arial'>, the <st1:City w:st="on"><st1:place + w:st="on">York</st1:place></st1:City> review fits well in a history of + attempts to downgrade possible risks associated with expo-sure to fluoride. + Selection of data, inconsistent use of exclusion criteria, disregard of experimental + studies which could have offered a clue to proper evaluation of + epidemiological investigations render the <st1:City w:st="on"><st1:place + w:st="on">York</st1:place></st1:City> review useless. Either the <st1:City + w:st="on"><st1:place w:st="on">York</st1:place></st1:City> team was not + really interested (to say the least), aimed at supporting proponents´ views, + or was hopelessly lost in its task.</span><span style='font-size:11.0pt'> <br> + <o:p></o:p></span></p> + <p><b><span style='font-size:11.0pt;font-family:Arial'>References:</span></b><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>American Dental + Association (1952): "<st1:State w:st="on"><st1:place w:st="on">Washington</st1:place></st1:State> + News Letter", J. Am. Dent. Assoc. 44: 461</span><span style='font-size: + 11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Cohn P.D. (1992): "A + brief report on the association of drinking water fluoridation and the + incidence of osteosarcoma among young males"; New Jersey Department of + Health, Nov. 8</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Doll R., Kinlen L. + (1977): "Fluoridation of water and cancer mortality in the <st1:country-region + w:st="on"><st1:place w:st="on">U.S.A.</st1:place></st1:country-region>"; + The Lancet I (June 18):1300</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Dophuoc H., Bompart G., + Bourbon P. (1981): "Effects of hydrogen fluoride on benzo(a)pyrene and + dimethylnitrosamine metabolism in rats"; Naturwiss. 68: 621</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Dophuoc H., Bompart G., + Bourbon P., Bouteille L. (1983): "Action du fluorure sur le métabolisme + hépatique de la diméthyl-nitrosamine et du benzo(a)pyrène chez le rat"; + Toxicol. Eur. Res. 5: 31</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Fredrickson D.S. (1976): + Letter to Hon. J. J. Delaney, Feb. 6, 1976; reproduced in: The National + Cancer Program, Part II: Fluoridation of Public Drinking Water , + Hearings before a subcommittee of the committee on government operations, + House of Representatives, 95th Congress, 1st session, Sept. 21 and Oct. 12, + 1977; Washington, p. 356</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Graham J.R., Burk D., + Morin P. (1987): "A current restatement and continuing reappraisal + concerning demographic variables in American time-trend studies on water fluoridation + and human cancer"; Proc. Pennsylv. Acad. Sci. 61:138 </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Irving C.C. (1966): + "Enzymatic deacetylation of N-Hydroxy-2-Acetylaminofluorene by liver + microsomes"; Cancer Res. 26:1390</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Jones <st1:country-region + w:st="on"><st1:place w:st="on">C.A.</st1:place></st1:country-region>, + Callaham M.F., Huberman E. (1988): "Sodium fluoride promotes + morphological transformation of Syrian Ham-ster Embryo cells"; + Carcinogenesis 9:2279</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Kinlen L. (1974): + "Cancer incidence in relation to fluoride level in water supplies"; + Commun. Health 6:69</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Kinlen L. (1975): + "Cancer incidence in relation to fluoride level in water supplies"; + Brit. Dent. J. 138:221</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Kinlen L., Doll R. + (1977): "Cancer and Fluoride"; The Lancet II, 1039</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Kraybill H. (1977): + "The National Cancer Program, Part II: Fluoridation of Public Drinking + Water, Hearings before a sub-committee of the committee on government + operations, House of Representatives, 95th Congress, 1st session, Sept. 21 + and Oct. 12, 1977; Washington , Government Printing Office, p. 239</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Lasne C., Lu Y.P., + Chouroulinkov L.(1988):"Transforming activities of sodium fluoride in + cultured Syrian Hamster Embryo and BALB/3T3 cells"; Cell Biol. Toxicol. + 4:311 </span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Mahoney M.C., Nasca P.C., + Burnett W.S., Melius J.M. (1991): "Bone cancer incidence rates in <st1:place + w:st="on"><st1:PlaceName w:st="on">New York</st1:PlaceName> <st1:PlaceType + w:st="on">State</st1:PlaceType></st1:place>: Time trends and fluoridated + drinking water"; Am. J. Publ. Health 81:475</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>McDonagh M., Whiting P., + Bradley M., Cooper J., Sutton A., Chestnutt I., Misso K., Wilson P., Treasure + E., Kleijnen J. (2000): "A systematic review of public water + fluoridation", NHS Centre for Reviews and Dissemination, University of + York</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Meiers P. (1984): + "Zur Toxizität von Fluorverbindungen mit besonderer Berücksichtigung der + Onkogenese"; Verlag für Medizin, <st1:City w:st="on"><st1:place w:st="on">Heidelberg</st1:place></st1:City></span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Meiers P. (1986): + "Experimente ueber Fluoridwirkungen im Krebsgeschehen", + Erfahrungsheilkunde No. 6:424-432</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>NTP (1985): "Statement + to accompany preliminary data tables from the NTP two-year sodium fluoride + study performed Dec. 1981 to Dec. 1983 – prepared July 29, 1985"</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>NTP (1990): + "Toxicology and carcinogenesis studies of sodium fluoride (CAS No. + 7681-49-4) in F344/N rats and B6C3F1 mice (Drinking Water Studies)", + National Toxicology Program, Technical Report Series 393, U.S. Department of + Health and Human Services</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><st1:place w:st="on"><span style='font-size:11.0pt;font-family:Arial'>Oldham</span></st1:place><span + style='font-size:11.0pt;font-family:Arial'> P.D., Newell D.J. (1977): + "Fluoridation of Water Supplies and Cancer – A Possible + Association?"; Appl. Statist. 26:125</span><span style='font-size:11.0pt'> + <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Oldham P.D., Newell D.J. + (1979): "Letter to the editors"; Appl. Statist. 28: 184</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Perkins C.E. (1952): + "The truth about water fluoridation"; published by the Fluoridation + Educational Society, <st1:place w:st="on"><st1:City w:st="on">Washington</st1:City> + <st1:State w:st="on">D.C.</st1:State></st1:place>, pp. 32-33</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Schepers G.W.H. (1961): + "Neoplasia experimentally induced by beryllium compounds"; Progr. + Exp. Tumor Res. 2:203</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Schlesinger E.R., Overton + D.E., Riverhead L.I., Chase H.C., Cantwell K.T. (1956): + "Newburgh-Kingston caries-fluorine study. XIII. Pediatric findings after + ten years"; J. Am. Dent. Assoc. 52:296</span><span style='font-size: + 11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Schuld A. (2000): + "UK Review", http://www.bruha.com/fluoride/html/uk_review.html + (Oct. 2000)</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Smith A. H. (1980): + "An examination of the relationship between fluoridation of water and + cancer mortality in 20 large <st1:country-region w:st="on"><st1:place w:st="on">US</st1:place></st1:country-region> + cities"; New Zealand Med. J. 91:413</span><span style='font-size: + 11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Swanberg H. (1953): + "Fluoridation of water and its relation to cancer", <st1:State + w:st="on"><st1:place w:st="on">Mississippi</st1:place></st1:State> Valley + Medical Journal 75:125</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Tannenbaum A., + Silverstone H. (1949): "Effect of low environmental temperature, + dinitrophenol, or sodium fluoride on the formation of tumors in mice", + Cancer Res. 9:403</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Taylor A. (1952): + Testimony, Feb. 19, "Chemicals in Food and Cosmetics", Hearings + before the House Select Committee to investigate the use of chemicals in + foods and cosmetics, House of Representatives, 82nd Congress, 2nd session, + pursuant to H. Res. 74 and H. Res. 447, Part 3, U. S. Government Printing + Office</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Taylor A. (1954): + "Sodium fluoride in the drinking water of mice", Dental Digest + 60:170</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Taylor A., Taylor N.C. + (1965): "Effect of sodium fluoride on tumor growth", Proc. Soc. + Exp. Biol. Med. 119:252</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Tsutsui T., Suzuki N., + Ohmori M.(1984): "Sodium fluoride-induced morphological and neoplastic + transformation, chromo-some aberrations, sister chromatid exchanges, and + unscheduled DNA synthesis in cultured Syrian Hamster Embryo cells"; + Cancer Res. 44:938</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>USPHS (1991): + "Review of fluoride. Benefits and Risks. Report of the ad hoc + subcommittee on fluoride of the Committee to coordinate environmental health + and related programs", Department of Health and Human Services, U. S. + Public Health Service; (Study of Hoover et al. (NCI) in Appendix F)</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Wagner H. J. (1981): + "Der Einfluß von Fluorid, Licht und 3,4-Benzpyren auf die Tumorinduktion + bei NMRI-Mäusen"; Inau-gural Dissertation, Erlangen-Nürnberg </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Whitmire C.E. (1981) : + "Carcinogenesis bioassay of sodium fluoride"; Tox-Tips 56:56-19</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>WHO (1969) : + "Principles for the testing and evaluation of drugs for carcinogenicity. + Report of a WHO Scientific Group", World Health Organization, Technical + Report Series, No. 426, <st1:City w:st="on"><st1:place w:st="on">Geneva</st1:place></st1:City>, + p. 19</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Yiamouyiannis J., Burk D. + (1975): "Cancer from our drinking water?", Congressional Record, + Proceedings and debates of the 94th Congress, 1st session</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Yiamouyiannis J. (1977): + "The National Cancer Program, Part II: Fluoridation of Public Drinking + Water", Hearings before a subcommittee of the committee on government + operations, House of Representatives, 95th Congress, 1st session, Sept. 21 + and Oct. 12, 1977; Washington, Government Printing Office</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Yiamouyiannis J., Burk D. + (1977): "Fluoridation and cancer. Age dependence of cancer mortality + related to artificial fluori-dation"; Fluoride 10:101</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Ziegelbecker R. (1987): + "Zur Frage eines Zusammenhangs zwischen Trinkwasserfluoridierung, Krebs + und Leberzirrhose"; gwf – Wasser – Abwasser 128: 111</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><b style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'><span + style='font-size:11.0pt;font-family:Arial'>Reprinted with permission of the + author, Peter Meiers.</span></i></b><b style='mso-bidi-font-weight:normal'><i + style='mso-bidi-font-style:normal'><span style='font-size:11.0pt'> <o:p></o:p></span></i></b></p> + <p><span style='font-size:11.0pt'><o:p> </o:p></span></p> + <p><b style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt; + font-family:Arial'>Andrew Saul is the <span class=grame>author of the books <i>FIRE</i></span><i> + YOUR DOCTOR!</i> How <i>to be Independently Healthy </i>(reader reviews at<i> + </i><a href="http://www.doctoryourself.com/review.html">http://www.doctoryourself.com/review.html</a> + ) and <i>DOCTOR YOURSELF: Natural Healing that Works.</i> (reviewed at <a + href="http://www.doctoryourself.com/saulbooks.html">http://www.doctoryourself.com/saulbooks.html</a> + ) </span></b><b style='mso-bidi-font-weight:normal'><span style='font-size: + 11.0pt'><o:p></o:p></span></b></p> + <p><b style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt; + font-family:Arial'>For ordering information, <a + href="http://www.doctoryourself.com/order.html">Click Here</a></span></b><b + style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt'> .</span></b><span + style='font-size:11.0pt'><br> + </span> <br> + </p> + </td> + </tr> + <tr style='mso-yfti-irow:1'> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal align=center style='text-align:center'><a + href="contact.html"><span style='text-decoration:none;text-underline:none'><img + border=0 width=55 height=60 id="_x0000_i1029" src="images/e-mail.gif"></span></a><br> + <a href="contact.html">Andrew W. Saul </a></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><o:p> </o:p></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <div class=MsoNormal align=center style='text-align:center'> + <hr size=2 width="100%" align=center> + </div> + <p class=MsoNormal><span style='font-size:7.5pt'>AN IMPORTANT NOTE: + This page is not in any way offered as prescription, diagnosis nor treatment + for any disease, illness, infirmity or physical condition. Any form of + self-treatment or alternative health program necessarily must involve an + individual's acceptance of some risk, and no one should assume + otherwise. Persons needing medical care should obtain it from a + physician. 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