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Saul, PhD"> +<meta name=Description +content="How much niacin is enough? Here is a simple way to determine your personal level of this important B-vitamin."> +<meta name=KeyWords +content="niacin, niacinamide, B-3, Abram Hoffer, Andrew Saul, Saul, nicotinic acid, cholesterol, sleep, vitamin, orthomolecular, flush, Hawkins, Linus Pauling, relax"> +<!--[if gte mso 9]><xml> + <o:shapedefaults v:ext="edit" spidmax="2050"/> +</xml><![endif]--><!--[if gte mso 9]><xml> + <o:shapelayout v:ext="edit"> + <o:idmap v:ext="edit" data="1"/> + </o:shapelayout></xml><![endif]--> + +<!-- ADD style1 ===================== --> + +<style type="text/css"> +#TFlag + { + float:right; + font-size:105%; + line-height:105%; + padding:.15 em; + margin:.15 em; + } +#BanLeft + { + float:left; + font-size:85%; + line-height:85%; + padding:.15 em; + margin-left:6px; + margin-right:6px; + } + +img.top + { + vertical-align:text-top; + } + +</style> + +<!-- END ADD style1 ===================== --> + +</head> + +<body bgcolor=white background="images/architek0H.gif" lang=EN-US link=blue +vlink=blue style='tab-interval:.5in'> + +<!-- ADD TFlag ===================== --> +<table class="MsoNormalTable" border="0" cellpadding="0" cellspacing="0" > +<tbody> +<tr> +<td> +<span id="TFlag"> +<a href="#translator_block"> + Translate this page + <img class="top" src="images/TranslateFlag.jpg" alt="translate gadget at page bottom" height="36" /> + </a> +<br /> +</span> + +<!-- ADD New_Banner ===================== --> +<span id="BanLeft"> +<img class="top" alt="" src="images/DY Header.jpg" /> +<!-- END New_Banner ===================== --> +<!-- ADD Start_img ===================== --> +<a href="http://www.andrewsaul.com/websq/"><img class="top" alt="" style="margin-left:12px;" src="images/Get started.jpg" alt="Start Today: Good Health -- free ebook download" ></a> +</span> +<!-- END Start_img ===================== --> +</td> +</tr> +</tbody> +</table> + +<!-- END ADD TFlag ===================== --> + +<div class=Section1> + +<!-- ==== REMOVED: <p class="MsoNormal"> --to-- </td></tr></tbody></table> ==== --> + + +<div class=MsoNormal align=center style='text-align:center'> + +<hr size=2 width="100%" align=center> + +</div> + +<table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 + style='mso-cellspacing:0in;mso-padding-alt:0in 0in 0in 0in'> + <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> + <td width=132 valign=top style='width:99.0pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><span style='color:red'>Niacin Saturation </span> <br> + <a href="index.html">Home</a></p> + </td> + <td width=18 style='width:13.5pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><o:p> </o:p></p> + </td> + <td valign=top style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><b><span style='font-family:Arial'>HOW TO DETERMINE A + SATURATION LEVEL OF NIACIN</span></b> </p> + <p><span style='font-family:Arial'> </span><span style='font-size:11.0pt; + font-family:Arial'>Niacin is vitamin B-3, one of the water soluble B-complex + vitamins. One of niacin's unique properties is its ability to help you + naturally relax and get to sleep more rapidly at night. And it is well + established that niacin helps reduce harmful cholesterol levels in the + bloodstream. Abram Hoffer, M.D., Ph.D. explains: "Niacin is one of the + best substances for elevating high density lipoprotein cholesterol (the + "good cholesterol) and so decreases the ratio of the total cholesterol + over<span class=GramE> high</span> density cholesterol." </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Another niacin feature is + its ability to greatly reduce anxiety and depression. Yet another + feature of niacin is that it dilates blood vessels and creates a sensation of + warmth, called <span class=GramE>a "niacin flush."</span> + This is often accompanied with a blushing of the skin. It is this + "flush" or sensation of heat that indicates a temporary saturation + of niacin, and that is our topic here.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> When you flush, you + can literally see and feel that you've taken enough niacin. The idea is to + initially take just enough niacin to have a slight flush. This means a + pinkness about the cheeks, ears, neck, forearms and perhaps elsewhere. A + slight niacin flush should end in about fifteen minutes or so. If you take too + much niacin, the flush may be more pronounced and longer lasting. If + you flush beet red for half an hour and feel weird, well, you took too much. + And <span class=GramE>a large dose of niacin on an empty stomach is</span> + certain to cause profound flushing.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>"With larger initial doses, the flush is more pronounced and lasts + longer," says Dr. Hoffer. "But with each additional dose, the + intensity of the flush decreases and in most patients becomes a minor + nuisance rather than an irritant. Niacin should always be taken immediately + after finishing ones meal." </span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> I have found that + the best way for me to accurately control the flushing sensation is to start + with very small amounts of niacin and gradually increase until the first + flush is noticed. One method is to start with a mere 25 milligrams (25 + mg) three times a day, say with each meal. The next day, try 50 mg at + breakfast, 25 mg at lunch and 25 mg at supper. The following day, one + might try 50 mg at breakfast, 50 mg at <span class=GramE>lunch,</span> and 25 + mg at supper. And, the next day, 50 mg at each of the three meals. The + next day, 75 mg, 50 mg and 50 mg. Then, 75. 75 and 50, and so + on. In this way you have increased at the easy rate of only 25 mg per + day. One would continue to increase the dosage by 25 mg per day until + the flush occurs. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> It is difficult to + predict a saturation level for niacin because each person is different. As + a general rule, the more you hold, the more you need. If you flush + early, you don't need much niacin. If flushing doesn't happen until a + high level, then your body is obviously using the higher amount of the + vitamin.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> Now that you've had + your first flush, what next? Since a flush indicates saturation of + niacin, it is desirable to continue to repeat the flushing, just very + slightly, to continue the saturation. This could be done three or more + times a day. To get to sleep sooner at night, niacin can be taken to + saturation at bedtime, too. You might be asleep before you even notice + the flush.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> An important point + here is that niacin is a vitamin, not a drug. It is not habit + forming. Niacin does not require a prescription because it is that + safe. It is a nutrient that everyone needs each day. Different + people in different circumstances require different amounts of niacin.</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> Says Dr. Hoffer: + "A person's "upper limit is that amount which causes nausea, and, + if not reduced, vomiting. The dose should never be allowed to remain at + this upper limit. The usual dose range is 3,000 to 9,000 milligrams daily + divided into three doses, but occasionally some patients may need more. The + toxic dose for dogs is about 5,000 milligrams per 2.2 pounds (1 kilogram) + body weight. We do not know the toxic dose for humans since niacin has never + killed anyone."</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> Inevitable + physician skepticism and questions about niacin's proven safety and + effectiveness are best answered in <i>Orthomolecular Psychiatry</i>, edited + by David Hawkins, M.D. and Linus Pauling, Ph.D. This nearly 700 page + textbook is the standard reference for details on niacin therapy. <i><span + style='mso-bidi-font-weight:bold'>Persons with a history of heavy alcohol + use, liver disorders, diabetes, or experiencing pregnancy will especially want to have + their physician monitor their use of niacin in quantity.</span></i> Monitoring + long-term use of niacin is a good idea for anyone. It consists of + having your doctor check your liver function with a simple blood test. </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> Plain and simple + niacin may be purchased in tablets at any pharmacy or health food + store. Tablets typically are available in 50 mg, 100 mg, or 250 mg + dosages. The tablets are usually scored down the middle so you can break + them in half easily. You can break the halves in <span class=GramE>half,</span> + too, to get the exact amount you want. </span><span style='font-size: + 11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> If a niacin tablet + is taken on an empty stomach, a flush will occur (if it is going to occur at + all) within about 20 minutes. If niacin is taken right after a + meal, a flush may be delayed. In fact, the flush may occur long enough + afterwards that you forgot that you took the niacin! Don't let the flush + surprise you. Remember that niacin does that, and you can monitor it + easily. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> If you want a flush + right away, you can powder the niacin tablet. This is easily done by + crushing it between two spoons. Powdered niacin on an empty stomach can + result in a flush within minutes. Sustained release niacin is often + advertised as not causing a flush at all. This claim may not be + completely true; sometimes the flush is just postponed. It would + probably be difficult to determine your saturation level with a sustained- or + time-released product. They are also more costly. But the biggest + reason to avoid sustained-release niacin is that most reports of side effects + stem from use of that form.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> There is nothing + wrong with <span class=SpellE>niacinAMIDE</span>, by the way. That form + of vitamin B-3 is frequently found in multiple vitamins and B-complex + preparations. Niacinamide does not cause a flush at all. In my opinion, + it is less effective in inducing relaxation and calming effects. Niacinamide + also does not lower serum cholesterol. This is an + important distinction to make when purchasing.</span><span style='font-size: + 11.0pt'> <o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'> It + is a good idea to take all the other B-complex vitamins in a separate + supplement in addition to the niacin. The B-vitamins, like professional + baseball players, work best as a team. Still, the body seems to need + proportionally more niacin than the other B vitamins. Even the U.S. + Recommended Daily Allowance (RDA) for niacin is much more than for any other + B-vitamin. Many physicians consider the current RDA for niacin of only + 20 mg to be way too low for optimum health. While the government + continues to discuss this, it is possible to decide for yourself based on the + success of doctors that use niacin for their patients every day. </span><span + style='font-size:11.0pt'> </span><span style='font-size:11.0pt;font-family: + Arial'><o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span + style='font-size:11.0pt;font-family:Arial'>TO FLUSH OR NOT TO FLUSH?</span></b><span + style='font-size:11.0pt;font-family:Arial'> That is this reader’s + question:<o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p class=MsoNormal><i style='mso-bidi-font-style:normal'><span + style='font-size:11.0pt;font-family:Arial'>”We have learned a great + deal from your site and your books and also enjoy them. We have also + incorporated some of your suggestions in our lifestyle. My question for you + is an attempt to clarify what seems to be a difference of opinion about the + niacin flush between you and Dr. Hoffer. He had written <span class=GramE>( </span><a + href="http://www.doctoryourself.com/hoffer_niacin.html" target=_blank">http://www.doctoryourself.com//hoffer_niacin.html</a> + <span style='mso-spacerun:yes'> </span>) that the niacin flush is normal with + many people and will diminish or go away as the patient continues to use + niacin at his recommended level of 3,000 milligrams per day. You, however, + state that the flush is an indication of no niacin deficiency. Who is correct or am I + misinterpreting one of you?”<o:p></o:p></span></i></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>Andrew + Saul’s Response: <o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>This is + how I look at it: Generally speaking, people in fairly good health usually + choose to increase their doses gradually in order to minimize flushing. If + they do increase the dose slowly, what I describe is pretty accurate. For + instance, I've been taking niacin for years, in daily but varying doses + depending on my stress level or dietary intake. I know by the flush when I've + had enough for the moment. It is like turning off the hot water when the tub + is full enough for a nice bath. Dr Hoffer is highly experienced with serious + psychiatric cases. Such patients have a niacin dependency, not a mere + deficiency. Let’s let him speak for himself:<o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>Abram + Hoffer, MD, writes: <o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>“We + are both correct. Most people flush at the beginning and gradually get + adapted to it unless they stop for a few days and then resume it. A few + cannot ever get used to it, and they take the no-flush preparations. But the + intensity of the flush is very variable. Generally people who need it the + most flush the least. That includes arthritics, schizophrenics, and elderly + people with cardiovascular problems. Some schizophrenics do not flush until + they get well and then they do. But the presence of the flush or its + intensity can not be uniquely used measure the need as there are too many + variables such as food in the stomach, whether the drink with it is hot or + cold, the kind of food, other medication. Antipsychotics reduce the intensity + of the flush as do aspirin and antihistamines.”<o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>RECOMMENDED <st1:City + w:st="on"><st1:place w:st="on">READING</st1:place></st1:City>:</span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + + <p><i style='mso-bidi-font-style:normal'><span style='font-size:11.0pt; + font-family:Arial;mso-bidi-font-weight:bold'><b>Niacin: The Real Story</i></b> by Abram Hoffer, Andrew W. Saul and Harold D. Foster. <span style='font-size:11.0pt; + font-family:Arial'>Reviewed at </span><span style='font-size:11.0pt'><a + href="http://www.doctoryourself.com/niacinreviews.html" target="_blank">http://www.doctoryourself.com/niacinreviews.html</a><o:p></o:p></span></p> + + <p><i style='mso-bidi-font-style:normal'><span style='font-size:11.0pt; + font-family:Arial;mso-bidi-font-weight:bold'><b>Orthomolecular Medicine for Everyone</i></b> by Abram Hoffer and Andrew W. Saul. <span style='font-size:11.0pt; + font-family:Arial'>Reviewed at </span><span style='font-size:11.0pt'><a + href="http://www.doctoryourself.com/orthomolecular.html" target="_blank">http://www.doctoryourself.com/orthomolecular.html</a><o:p></o:p></span></p> + + + + <p><span style='font-size:11.0pt;font-family:Arial'>The above Dr. Hoffer + quotes are from a private communication, April 7, 2002 <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>Copyright C 2013, 2008, and previous years by Andrew W. Saul.<o:p></o:p></span></p> + <p><b style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt; + font-family:Arial'>Andrew Saul is the <span class=GramE><span class=grame>author + of the books <i>FIRE</i></span></span><i> YOUR DOCTOR!</i> How <i>to be + Independently Healthy </i>(reviews at<i> </i><a + href="http://www.doctoryourself.com/review.html" target="_blank">http://www.doctoryourself.com/review.html</a> + ) and <i>DOCTOR YOURSELF: Natural Healing that Works.</i> (reviewed at <a + href="http://www.doctoryourself.com/saulbooks.html" target="_blank">http://www.doctoryourself.com/saulbooks.html</a> + ) </span></b><b style='mso-bidi-font-weight:normal'><span style='font-size: + 11.0pt'><o:p></o:p></span></b></p> + + <p><span style='font-size:11.0pt; + font-family:Arial'>These books are all available from any internet book seller, but are not for sale at this website. + + <p><o:p> </o:p></p> + </td> + </tr> + <tr style='mso-yfti-irow:1'> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal align=center style='text-align:center'><a + href="contact.html"><span style='text-decoration:none;text-underline:none'><img + border=0 width=55 height=60 id="_x0000_i1029" src="images/e-mail.gif"></span></a><br> + <a href="contact.html" target="_blank">Andrew W. Saul</a></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><o:p> </o:p></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <div class=MsoNormal align=center style='text-align:center'> + <hr size=2 width="100%" align=center> + </div> + <p class=MsoNormal><span style='font-size:7.5pt'>AN IMPORTANT NOTE: + This page is not in any way offered as prescription, diagnosis nor treatment + for any disease, illness, infirmity or physical condition. Any form of + self-treatment or alternative health program necessarily must involve an + individual's acceptance of some risk, and no one should assume + otherwise. Persons needing medical care should obtain it from a + physician. Consult your doctor before making any health decision. </span> + </p> + <p><span style='font-size:7.5pt'>Neither the author nor the webmaster has + authorized the use of their names or the use of any material contained within + in connection with the sale, promotion or advertising of any product or + apparatus. 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