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| author | luxagraf <sng@luxagraf.net> | 2020-11-29 13:17:50 -0500 |
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| committer | luxagraf <sng@luxagraf.net> | 2020-11-29 13:17:50 -0500 |
| commit | 642b5821695f286c6e2510c45a33e16eec249d65 (patch) | |
| tree | 317f03ca88e34d5fd68514bcad406b89f7207d5e /reference/www.doctoryourself.com/pain.html | |
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Saul, PhD"> +<meta name=KeyWords +content="natural, pain, relief, analgesia, phenylalanine, DLPA, amino acid, vitamin C, enkephalin, endorphin, migraine, neuralgia, arthritis, tooth"> +<meta name=Description +content="Chronic pain that is unresponsive to other measures may be effectively treated with an amino acid. Safety and dosage information is provided, with medical references."> +<!--[if gte mso 9]><xml> + <o:shapedefaults v:ext="edit" spidmax="2050"/> +</xml><![endif]--><!--[if gte mso 9]><xml> + <o:shapelayout v:ext="edit"> + <o:idmap v:ext="edit" data="1"/> + </o:shapelayout></xml><![endif]--> + +<!-- ADD style1 ===================== --> +<style type="text/css"> +#TFlag +{ + float:right; + font-size:105%; + line-height:105%; + padding:.15 em; + margin:.15 em; +} +img.top +{ + vertical-align:text-top; +} +</style> +<!-- END ADD style1 ===================== --> + +</head> + +<body bgcolor=white background="images/architek0H.gif" lang=EN-US link=blue +vlink=blue style='tab-interval:.5in'> + +<!-- ADD TFlag ===================== --> +<span id ="TFlag"> + <a href="#translator_block"> + Click here to translate this page. + <img class="top" SRC="images/TranslateFlag.jpg" alt="translate gadget at page bottom" height=36> + </a> +</span> +<!-- END ADD TFlag ===================== --> + +<div class=Section1> + +<p class=MsoNormal> </p> + +<table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 + style='mso-cellspacing:0in;mso-padding-alt:0in 0in 0in 0in'> + <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes;mso-yfti-lastrow:yes'> + <td width=132 style='width:99.0pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><img width=117 height=105 id="_x0000_i1025" + src="images/logo1.GIF"></p> + </td> + <td width=16 style='width:12.0pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><o:p> </o:p></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><img width=365 height=60 id="_x0000_i1026" + src="images/dystitle2.JPG"><br> + <img width=365 height=20 id="_x0000_i1027" src="images/dysaut.JPG"></p> + </td> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><b><span style='font-family:Arial'>Pain Relief Without + Drugs</span></b></p> + </td> + </tr> +</table> + +<div class=MsoNormal align=center style='text-align:center'> + +<hr size=2 width="100%" align=center> + +</div> + +<table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 + style='mso-cellspacing:0in;mso-padding-alt:0in 0in 0in 0in'> + <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> + <td width=132 valign=top style='width:99.0pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><span style='color:red'>Pain Relief</span> <br> + <a href="index.html">Home Page</a> <br> + <a href="http://www.doctoryourself.com/contents.html"></a> </p> + </td> + <td width=18 style='width:13.5pt;padding:0in 0in 0in 0in'> + <p class=MsoNormal><o:p> </o:p></p> + </td> + <td valign=top style='padding:0in 0in 0in 0in'> + <p class=MsoNormal><span style='font-family:Arial'>D,L-PHENYLALANINE AND + VITAMIN C: <o:p></o:p></span></p> + <p class=MsoNormal><span class=GramE><span style='font-family:Arial'>TWO + DRUG-FREE APPROACHES TO CHRONIC PAIN </span> <br> + <span style='font-family:Arial'> </span> <br> + <span style='font-size:14.0pt;font-family:Arial'>There</span></span><span + style='font-size:14.0pt;font-family:Arial'> are an almost uncountable number + of brands of pain relievers</span><span style='font-family:Arial'> </span><span + style='font-size:11.0pt;font-family:Arial'>on the medical market. Were + pain due to a drug deficiency, they might have more to offer. </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>I am not in favor of + pain except as a warning. Pain is often our wake-up call to action, when + our bodies need to get a message to and an effective response from our busy + brain. As protests on the Capitol Mall get the attention of lawmakers in + <st1:State w:st="on"><st1:place w:st="on">Washington</st1:place></st1:State> + (sometimes, anyway), so does pain act as the squeaky wheel demanding + grease. </span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Putting in earplugs + does not fix a squeaky wheel. The best pain relief will help cure the + cause of pain. At the very least, we want the hurt to go away + temporarily without harmful side effects. So we have therapeutic value + and safety as benchmarks for pain relief. </span><span style='font-size: + 11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Here are two + alternatives to pharmaceutical products: vitamin C and D<span + class=GramE>,L</span>-Phenylalanine.<o:p></o:p></span></p> + <p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><span + style='mso-spacerun:yes'> </span></span><span style='font-size:11.0pt'><span + style='mso-spacerun:yes'> </span><o:p></o:p></span></p> + <p style='margin:0in;margin-bottom:.0001pt'><b><span style='font-size:11.0pt; + font-family:Arial'>VITAMIN C (Ascorbic Acid) ANALGESIA </span></b><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> At high intake + levels, Vitamin C is known to reduce inflammation and act to as a natural + antibiotic and antihistamine. These properties are surprising enough <span + class=GramE>to</span> many, but one of the biggest surprises ever occurred + during the 1970's in <st1:place w:st="on"><st1:country-region w:st="on">Scotland</st1:country-region></st1:place> + at the Vale of <span class=SpellE>Leven</span> Hospital. There, Ewan + Cameron, M.D. was giving ten grams (10,000 milligrams) of vitamin C + intravenously each day to terminally ill cancer patients. The study was + about vitamin C and cancer, but the unexpected finding was in pain + relief. </span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>In <st1:place w:st="on"><st1:country-region + w:st="on">Great Britain</st1:country-region></st1:place> at the time, it was + policy to provide terminal patients with any and all pain relief available, + including addictive narcotics such as heroin. The argument was simply + that if one were dying anyway, a drug's analgesic value outweighs any + drawbacks such as dependency. Dr. Cameron and Dr. Linus Pauling wrote in <i>Cancer + and Vitamin C</i> (1981; revised 1993):<o:p></o:p></span></p> + <p style='margin:0in;margin-bottom:.0001pt'><span style='font-size:11.0pt'><o:p> </o:p></span></p> + <p class=MsoNormal><i><span style='font-size:11.0pt;font-family:Arial'>“Cameron + and Baird reported (in 1973) that the first five ascorbate-treated patients + who had been receiving large doses of morphine or heroin to control pain were + taken off these drugs a few days after the treatment with vitamin C was + begun, because the <b style='mso-bidi-font-weight:normal'>vitamin C seemed to + diminish the pain to such an extent that the drug was not needed. Moreover, + none of these patients asked that the morphine or heroin be given to them- + they seemed not to experience any serious withdrawal signs or symptoms.”</b> + </span></i><span style='font-size:11.0pt;font-family:Arial'>(page xii) </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Any vitamin that + approaches the pain relieving power of morphine or heroin must be considered + some kind of analgesic indeed. The fact that 13 out of 100 terminally + ill cancer patients given vitamin C were still alive and apparently free of + cancer after five years is some kind of miracle. </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Although quite a lot + of vitamin C is needed for results, it is a remarkably safe and rather simple + therapy. Additional information will be found in Dr. Cameron's "Protocol + for the Use of Intravenous Vitamin C in the Treatment of Cancer," (<a + href="http://www.doctoryourself.com/cameron.html">click here to read it</a>) + and in the many vitamin C articles posted at this website (and easily found + with a quick website search from the <a href="http://www.doctoryourself.com/">www.doctoryourself.com</a> + <span class=SpellE>mainpage</span>.)</span><span style='font-size:11.0pt'> <br> + <br> + </span><b><span style='font-size:11.0pt;font-family:Arial'>D- or + DL-PHENYLALANINE </span></b><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> Unlike + left-handed, essential L-Phenylalanine, the D- or "right-handed" + form of this common amino acid is not actually a nutrient but an amino acid + analgesic. It is non-prescription but is rather costly for an effective + dose. Practitioners using DLPA (Dextro-<span class=SpellE>Levo-Phenyl-Alanine</span>) + normally employ it for chronic pain that is unresponsive to other + measures. Arthritis or lower back pain would be examples. While no + substitute for medical or chiropractic care, DLPA may well be a most suitable + companion. </span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>The dose of DLPA + needed may vary from person to person, and is generally determined by + starting with perhaps 1,000 mg daily for two weeks and then gradually + increasing to a level that provides relief. If 3,000 mg per day doesn't + work after a month's time, it probably will not work at all. About + two-thirds of those using it will report real improvement in this time. + If they don't, then stop. There is no point in wasting money. </span><span + style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>For this stuff is not + cheap. Tablet potency is commonly around 300 to 500 mg, so a person might + well need to take quite a few each day. I used to think that DLPA was way too + pricey until I saw a few prescriptions where the pills cost several dollars + apiece (and this was over a decade ago, long before the even more expensive + "Viagra").</span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>The good news is that + persons reporting pain relief will generally be able to LOWER their dose + gradually and will often be able to maintain pain-free status with less DLPA + than before. It is a bit unusual for an analgesic substance to work + BETTER over time and require LESS; the opposite is the rule. (Consider + morphine, for instance.) DLPA has a long duration of action yet the body + does not seem to build up a tolerance to it. </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>You will probably not + find just "D-phenylalanine" for sale, hence the focus here on + DLPA. It is the D-form that is active; you CANNOT therefore substitute + the <span class=SpellE>levo</span>- ("L") form that is so widely + found, at far lower cost, in foods and stores. The "L" form will + not work. If the bottle does not specifically state its contents as + "DL," you can be certain they are just trying to sell you the + useless "L" form.</span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Our earlier criteria + for natural pain relievers included safety and healing value. The safety of + DLPA is very good indeed. It is non-addictive and virtually non-toxic. + Some estimates place its safety on a par with vitamin C or fructose. Still, + it is not to be used during pregnancy. Persons with <span class=SpellE>phenylketonuria</span> + (PKU) obviously should not take any extra phenylalanine. Persons with + high blood pressure should take DLPA after meals. Outside of these, + there are virtually no adverse effects. </span><span style='font-size: + 11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Added value may come + from the fact that phenylalanine is converted by the body into <span + class=SpellE>phenylethylamine</span>. Low levels of <span class=SpellE>phenylethylamine</span> + are correlated with clinical depression; if DLPA raises these levels there is + a real biochemical benefit. As a pain-killer, it seems to act by keeping + enzymes called <span class=SpellE>enkephalinase</span> and <span + class=SpellE>carboxypeptidase</span> A from breaking down the body's own + morphine-like natural painkillers, the <span class=SpellE>enkephalins</span> + and the endorphins. This makes a lot of sense: if the body relieves its + own pain, a safe mechanism is probably at work. DLPA appears to assist + that mechanism. </span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>Research has + indicated that migraine, joint pains, neuralgia and even postoperative pain + respond to DLPA, and it has been reported to reduce inflammation. DLPA + does not deaden normal sensation even when taken for a lengthy period. Prescribed + medication usually may still be taken with DLPA without interference. Consult + the <i>Physician's Desk Reference</i> ("PDR", found at any doctor's + office, pharmacy, or library) for information on any drug you may be taking + or considering.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'>The most dramatic + pain-relief case I have seen was when a friend of mine had a large number of + old dental fillings replaced within a short period of time. As a result, he + experienced ongoing and severe jaw pain that no pharmaceutical pain-killer + could touch, and the dentist tried them all. In desperation, my friend tried + DLPA, about 3,000 mg/day. He reported immediate improvement, and truly + profound relief shortly thereafter.</span><span style='font-size:11.0pt'> <o:p></o:p></span></p> + <p><span style='font-size:11.0pt;font-family:Arial'> REFERENCES ON D<span + class=GramE>,L</span>-PHENYLALANINE: </span><span style='font-size:11.0pt'> + <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>1. <span + class=SpellE>Balagot</span>, R.C., <span class=SpellE>Ehrenpreis</span>, S., + Greenberg, J. and <span class=SpellE>Hyodo</span>, M., "D-Phenylalanine + in Human Chronic Pain," Degradation of Endogenous <span class=SpellE>Opioids</span>: + Its Relevance in Human Pathology and Therapy, <st1:place w:st="on">S. + <span class=SpellE>Ehrenpreis</span></st1:place> and <span class=SpellE>Sicuteri</span>, + eds. <st1:State w:st="on"><st1:place w:st="on">New York</st1:place></st1:State>: + Raven Press, 1983 </span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>2. <span + class=SpellE>Balagot</span>, R.C., <span class=SpellE>Ehrenpreis</span>, S., + Kubota, K. and Greenberg, J., Advances in Pain Research and Therapy,<span + class=GramE> Vol</span>. 5, <span class=SpellE>Bonica</span>, <span + class=SpellE>Liebeskind</span> and <span class=SpellE>Albe-Fessard</span>, + ed., pp 289-293, <st1:State w:st="on"><st1:place w:st="on">New York</st1:place></st1:State>: + Raven Press, 1983 </span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>3. Beckman, H. et al, + "DL Phenylalanine in Depressed Patients: An Open Study," Journal of + Neural Transmission, 41:123-134, 1977 </span><span style='font-size: + 11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>4. Budd, K. "Use + of D-Phenylalanine, an <span class=SpellE>Enkephalinase</span> Inhibitor, in + the Treatment of Intractable Pain," Advances in Pain Research and + Therapy,<span class=GramE> Vol</span>. 5, <span class=SpellE>Bonica</span>, + <span class=SpellE>Liebeskind</span> and <span class=SpellE>Albe-Fessard</span>, + ed., pp 305-308, <st1:State w:st="on"><st1:place w:st="on">New York</st1:place></st1:State>: + Raven Press, 1983 </span><span style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>5. <span + class=SpellE>Ehrenpreis</span>, S., <span class=SpellE>Balagot</span>, R.C., <span + class=SpellE>Comaty</span>, J.E. and Myles, S.B. "<span class=SpellE>Naloxone</span> + Reversible Analgesia in Mice Produced by D-Phenylalanine and <span + class=SpellE>Hydrocinnamic</span> Acid, Inhibitors of <span class=SpellE>Carboxypeptidase</span> + A," Advances in Pain Research and Therapy, Vol. 3, <span class=SpellE>Bonica</span>, + <span class=SpellE>Liebeskind</span> and <span class=SpellE>Albe-Fessard</span>, + ed., pp 479-488, New York: Raven Press, 1978 </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>6. <span + class=SpellE>Ehrenpreis</span>, S., <span class=SpellE>Balagot</span>, R.C., + Myles, S., Advocate, C. and <span class=SpellE>Comaty</span>, J.E. + "Further Studies on the Analgesic Activity of D-Phenylalanine in Mice + and Humans," Proceedings of the International Narcotic Research + Club Convention, E. L. Way, ed., pp 379-382, 1979 </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>7. Heller, B. + "Pharmacological and Clinical Effects of D-Phenylalanine in Depression + and Parkinson's Disease," in Modern Pharmacology-Toxicology, <span + class=SpellE>Noncatecolic</span> <span class=SpellE>Phenylethylamines</span>, + Part 1, A.D. <span class=SpellE>Mosnaim</span> and M.E. Wolf, eds., pp + 397-417, New York: Marcel <span class=SpellE>Dekker</span>, 1978 </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br> + </span><span style='font-size:11.0pt;font-family:Arial'>8. <span + class=SpellE>Sabelli</span>, H.C. and <span class=SpellE>Mosnaim</span>, A.D. + "<span class=SpellE>Phenylethylamine</span> Hypothesis of Affective Behavior," American + Journal of Psychiatry, 131:695, 1974 </span><span style='font-size:11.0pt'> + <br> + </span><span style='font-size:11.0pt;font-family:Arial'> </span><span + style='font-size:11.0pt'> <br style='mso-special-character:line-break'> + <![if !supportLineBreakNewLine]><br style='mso-special-character:line-break'> + <![endif]><o:p></o:p></span></p> + <p><span style='font-size:10.0pt;font-family:Arial'>Copyright 2007, 2004 and + prior years by Andrew Saul.<o:p></o:p></span></p> + <p><b style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt; + font-family:Arial'>Andrew Saul is the <span class=GramE><span class=grame>author + of the books <i>FIRE</i></span></span><i> YOUR DOCTOR!</i> How <i>to be + Independently Healthy </i>(reader reviews at<i> </i><a + href="http://www.doctoryourself.com/review.html">http://www.doctoryourself.com/review.html</a> + ) and <i>DOCTOR YOURSELF: Natural Healing that Works.</i> (reviewed at <a + href="http://www.doctoryourself.com/saulbooks.html">http://www.doctoryourself.com/saulbooks.html</a> + ) </span><o:p></o:p></b></p> + <p><b style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt; + font-family:Arial'>For ordering information, <a + href="http://www.doctoryourself.com/order.html">Click Here</a></span> .<o:p></o:p></b></p> + <p><span style='font-size:10.0pt;font-family:Arial'><o:p> </o:p></span></p> + <p> </p> + </td> + </tr> + <tr style='mso-yfti-irow:1'> + <td style='padding:0in 0in 0in 0in'> + <p class=MsoNormal align=center style='text-align:center'><a + href="contact.html"><span style='text-decoration:none;text-underline:none'><img + border=0 width=55 height=60 id="_x0000_i1029" src="images/e-mail.gif"></span></a><br> + <a href="contact.html">Andrew W. 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