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<p class=MsoNormal><b><span style='font-family:Arial'>B-Vitamins</span></b></p>
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<p class=MsoNormal><span style='color:red'>B-Vitamins</span> <br>
<span style='color:#3366FF'><span style='mso-field-code:" HYPERLINK \0022\0022 "'><span
class=MsoHyperlink>Home</span></span></span></p>
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<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-family:Arial'>B-INFORMED ABOUT B-VITAMINS </span> <span
style='color:#3366FF'><o:p></o:p></span></b></p>
<p><span style='font-size:11.0pt;font-family:Arial'>The safety record of the
B-complex vitamins is extraordinarily good. Since their discovery,
beginning with thiamin (B-1) in 1911, many thousands of studies have verified
an unequaled therapeutic value of these essential substances. Side
effects have been rare, and toxicity is nearly nonexistent, even at the
highest doses. Some cautions are in order, of course, and here are some
of the most important. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Vitamin B-6 (pyridoxine)
has been reported to cause temporary neurological symptoms such as heaviness,
tingling or numbness of the limbs in persons taking very large doses.
It is very important to realize that such cases are not common, and when they
do occur usually result from huge doses of pyridoxine TAKEN ALONE. The
B-vitamins are a team, and work best as a team. Upsetting the balance by
taking a lot of just one is like devoting all your baseball practice time to
your pitcher. You might get a lot of strikeouts, but if anybody hits
one, you are in trouble. No one player has ever won a World Series by
himself, and no single B-vitamin can do the job that the whole
"team" can do. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>B-6 by itself in doses of
2,000 to 6,000 milligrams daily (that's one thousand to three thousand times
the US RDA!) can produce side effects and is therefore way too much to
take. Very, very few persons report symptoms on 1,000 mg daily, and
only the rarest reports go any lower. When taken with, or as part of, a
complete B-complex supplement, B-6 side effects other than <span class=GramE>a
harmless</span> deeper-colored urine are virtually unknown. </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Premenstrual tension
symptoms often improve dramatically with only a few hundred mg/day of extra
B-6. There is no need to "push the envelope" and take
thousands of milligrams when hundreds will do. At least 50 to 100 mg of
supplemental B-6 daily is a virtual necessity for women taking oral
contraceptives. The "pill" causes some abnormal physiological
changes that create a deficiency of B-6, as well as lower serum levels of
thiamine (B-1), and riboflavin (B-2), and niacin (B-3), and folic acid, and
B-12, and vitamin C! (Wynn, V. <i>Lancet</i>, March 8, 1975) </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Laboratory animals
receiving the human B-6 dose equivalent of just 75 mg daily do not get
strokes, even when fed a lousy diet (<i>Atherosclerosis</i>, vol. 22, 1975,
pp 125-127)<span class=GramE> Since</span> women on oral contraceptives
are three times more likely at any age to have a stroke, there is an
important lesson here. B-6 deficiency produces hardening of the
arteries (Rinehart and Greenberg, <i>American Journal of Pathology</i>, vol.
25, 1949, pp 481-496.) Furthermore, B-6 is necessary in order for your
body to produce lecithin. Lecithin, a lipid- transporting substance
from soy, has been used clinically to clear out fatty livers... and even
clogged arteries. Another connection. </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Niacin (vitamin B-3) has
been used in doses up to tens of thousands of milligrams per day for over 40
years by psychiatrists. It is an effective alternative treatment for
severe depression, psychotic behavior, and schizophrenia. Most
physicians have ignored niacin's usefulness until rather recently. Niacin has
finally gained popularity as one of the cheapest ways to lower serum
cholesterol. Changes in liver function tests have been reported in
persons taking one to five thousand milligrams daily of niacin BY
ITSELF. Three important points have generally gone unnoticed: </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> 1. Niacin is much
better tolerated when given with Vitamin C. Abram Hoffer, M.D. pioneered
high dose niacin therapy back in the 1950's. He repeatedly published his
observations that gram-sized doses of vitamin C greatly improve a patient's
niacin tolerance. Dr. Hoffer recommended at least as much
vitamin C per dose as niacin. With three thousand milligrams of
niacin per day, then, one would need a MINIMUM of three thousand milligrams
of vitamin C. The medical profession's unfounded resistance to large
doses of vitamin C is embarrassingly well known. It is useless to blame
niacin for side effects caused by ignoring expert medical advice on how to
use it correctly along with vitamin C. </span><span style='font-size:
11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> Vincent <span
class=SpellE>Zannoni</span> at the University of Michigan Medical School has
shown that vitamin C protects the liver itself. Even doses as low as 500
milligrams daily helped prevent fatty buildup and cirrhosis. 5,000 mg of
vitamin C per day appears to actually flush fats from the liver. (Ritter,
M. "Study Says Vitamin C Could Cut Liver Damage," Associated Press,
October 11, 1986) F. R. Klenner, M.D. showed that very large doses of
vitamin C (between 500 to 900 mg per kilogram body weight per day) can cure
hepatitis in two to four days (Smith, L. H., ed. <i>Clinical Guide To The Use
Of Vitamin C</i>, Life Science Press, Tacoma Washington, 1988, pp
22-23). </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> 2. Niacin is also
one of the team of B-vitamins and needs any massive intake to be at least
partly balanced with the rest of the B-complex, just like B-6 mentioned
above. Would you pay for a tune up for your car and change only one spark
plug? If you have several kids, would you feed only one? Would you pay
for cable TV if there were only one channel? Taking only one B-vitamin
is neither logical nor efficient. So avoid doing it unless there is a
good reason. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> 3. Many, perhaps
most, persons showing changes in their liver function tests
upon ingestion of large amounts of niacin have been using
alcohol. Accurate information about sizable alcohol consumption is very
difficult to get from a patient: the more they use, the less they'll
tell. Two thirds of all American adults drink alcohol, averaging out to
be about three drinks per day, seven days a week, <span class=GramE>52</span>
weeks a year. If you do not drink that much, then somebody out there is
drinking MORE. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> Alcohol does
nothing if it doesn't hurt the liver. The French have the highest
per capita consumption of alcohol in the world. They also have the
world's highest percentage of deaths from cirrhosis of the liver.
Working hard, the human liver can detoxify about one drink every two
hours. Know anyone who drinks at a faster rate than that? Then
marvel that they have a liver that functions at all. Alcohol is a drug,
and consumption and abuse is more widespread and more serious than most
persons imagine. Over two thirds of all hospital admissions of the
elderly are alcohol related. (New York State Office of Alcoholism and
Substance Abuse Services, <span class=SpellE>Oasas</span> Today, 1:1,
Sept-Oct. 1992) </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> The liver
undergoes profound changes in both its endoplasmic <span class=SpellE>reticula</span>
and its <span class=SpellE>microsomal</span> enzymes in order to
detoxify alcohol. The unbalanced introduction of very<span
class=GramE> large</span> doses of niacin to an overloaded liver may
well overtax an alcohol-strained system. This is likely where some
changes in liver function tests come from (<i>American Journal of
Medicine</i>, <span class=SpellE>vol</span> 86, April, 1989, page 431 and
vol. 87, August 1989, page 248; <i>American Journal of Cardiology</i>, vol.
64, October 1, 1989 page 728). </span><span style='font-size:11.0pt'>
<o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> 4. Any <span
class=SpellE>hepatotoxic</span> effects of niacin are almost invariably
associated with the sustained release form (<i>Journal of the
American Medical Association</i>, March 2, 1994). Sustained release
niacin generally enables higher doses with less "flushing."
However, that warm sensation called flushing indicates niacin
saturation. Sustained release delivery may therefore be hiding this sign
that the body has had enough niacin at a given time. </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'> 5. Simply reducing
the dosage reduces side effects. (Naito, H. "Reducing Cardiac
Deaths with <span class=SpellE>Hypolipidemic</span> Drugs," <i>Postgraduate
Medicine</i>, <span class=SpellE>vol</span> 82, no. 6, November 1987; <span
class=SpellE>Figge</span>, H. L. et al: "Nicotinic Acid: A Review of its
Clinical Use in the Treatment of Lipid Disorders," <i>Pharmacotherapy</i>,
Vol. 8, no. 5, 1988) Since the regular "immediate release" form
of niacin also is effective in lowering total cholesterol and actually
improves beneficial HDL levels, why not just use the plain tablets? Take
less, but more often, and you approximate the idea of a sustained release
tablet, but with a lower dose. If there is a flush, reduce the
dose. The idea is to be comfortable. It is better to be able to use less
of the vitamin for a long time than to use a lot, have trouble, and
quit. American physicians often over prescribe anyway, and niacin is no
exception. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Niacin is not a magic
cholesterol bullet, nor is cholesterol the only factor in heart
disease. Niacin is PART of the picture, part of the B-vitamin team, and
part of a total health program. Granted, niacin is indeed
important. This is shown by even our inadequate US RDA, which recommends
many times more niacin than any other B-vitamin. However, persons truly
seeking to lower their cholesterol need to eat more fiber, more vegetables
(especially carrots), more vitamins E and C, and to exercise more. They
also need to eat less sugar, less fat, less meat, and reduce
stress. There are ZERO harmful effects (and countless side BENEFITS) in
taking these steps. </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>People who do not want to
change their diet and do not want to change their lifestyle ask doctors for a
pill instead. There is no such thing as <span class=SpellE>monotherapy</span>
for cardiovascular disease. If there was, we'd all use it and be saving
literally a million lives each year. Is it really that big a surprise
that niacin alone isn't enough to do the job right? </span><span
style='font-size:11.0pt'> <br>
<o:p></o:p></span></p>
<p><b style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt;
font-family:Arial'>REFERENCES: </span></b><b style='mso-bidi-font-weight:
normal'><span style='font-size:11.0pt'> <o:p></o:p></span></b></p>
<p><i><span style='font-size:11.0pt;font-family:Arial'>Alcohol: </span></i><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Ray, O. and <span
class=SpellE>Ksir</span>, C. Drugs, Society and Human Behavior, chapter
9. <span class=SpellE>Mosby</span>, 1990<span class=GramE> (</span>I'm
sure most of the great book titles are already taken, so don't be fooled by
this one. This is an excellent book: clear, fact-filled and well written.) </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Williams, R. J. Nutrition
and Alcoholism (1951) and Alcoholism: The Nutritional Approach (1959) may be
out of print but are worth the search. </span><span style='font-size:
11.0pt'> <o:p></o:p></span></p>
<p><i><span style='font-size:11.0pt;font-family:Arial'>Therapeutic Uses of
the B-Vitamins:</span></i><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Bicknell and Prescott,
The Vitamins in Medicine, 3rd ed., 1953 (This out-of-print work stands as the
definitive summary of most all vitamin research up to the date of its
publication. There are many thousands of references here.) </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Cheraskin, et al: <span
class=SpellE>Psychodietetics</span>, Bantam Books, 1974 (A deservedly
popular book, loaded with references.)</span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Hoffer, A. and Walker,
M. Orthomolecular Nutrition, Keats, 1978 ("Orthomolecular"
essentially means "megavitamin." Good introductory
work.) </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Pauling, L. How To
Live Longer and Feel Better, Freeman, 1986. Revised and updated, 1996. (Still
the best single health book ever written. Here is a good place to begin
your investigation of vitamin therapeutics. </span><span style='font-size:
10.0pt;font-family:Arial'><a
href="http://www.doctoryourself.com/livelonger.html">http://www.doctoryourself.com/livelonger.html</a></span><span
style='font-size:11.0pt;font-family:Arial'> ) </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><i><span style='font-size:11.0pt;font-family:Arial'>Psychiatric Utility of
Niacin: </span></i><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Hawkins, D. and Pauling,
L. Orthomolecular Psychiatry, Freeman, 1973 (Here, in one big volume, is more
information than most doctors ever want to admit exists on using niacin,
especially in treating depression and psychoses.) </span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Hoffer, Abram. <span
class=GramE>Niacin</span> Therapy in Psychiatry, Charles Thomas, 1962 (This
is what started it all; note the publishing date. Nobody knows niacin
like Dr. Hoffer.) </span><span style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Hoffer, A. and Osmond,
H. The Chemical Basis of Clinical Psychiatry, Charles <span
class=SpellE>Thomas<span class=GramE>,<st1:place w:st="on"><st1:City w:st="on">Springfield</st1:City>,
<st1:State w:st="on">Ill.</st1:State></st1:place> (Even more in depth study
of the biochemistry and uses of niacin.) </span></span></span><span
style='font-size:11.0pt'> <o:p></o:p></span></p>
<p><i style='mso-bidi-font-style:normal'><span style='font-size:11.0pt;
font-family:Arial'>Remember to try your library's Interlibrary Loan service
to obtain out-of-print works. </span></i><i style='mso-bidi-font-style:
normal'><span style='font-size:11.0pt'> <o:p></o:p></span></i></p>
<p><span style='font-size:10.0pt'>Copyright<span class=GramE> C</span>
2007 and prior years Andrew W. Saul. <o:p></o:p></span></p>
<p><b style='mso-bidi-font-weight:normal'><span style='font-size:10.0pt;
font-family:Arial'>Andrew Saul is the <span class=GramE><span class=grame>author
of the books <i>FIRE</i></span></span><i> YOUR DOCTOR!</i> How <i>to be
Independently Healthy </i>(reader reviews at<i> </i><a
href="http://www.doctoryourself.com/review.html">http://www.doctoryourself.com/review.html</a>
) and <i>DOCTOR YOURSELF: Natural Healing that Works.</i> (reviewed at <a
href="http://www.doctoryourself.com/saulbooks.html">http://www.doctoryourself.com/saulbooks.html</a>
) </span><o:p></o:p></b></p>
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