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<p><span style='font-size:10.0pt;font-family:Arial;color:black'>Interview
with </span><span style='font-family:Arial;color:black'>MICHAEL HOLICK, M.D.</span><b
style='mso-bidi-font-weight:normal'><span style='font-size:11.0pt;font-family:
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<p><span style='color:red'>Michael Holick, M.D. </span><br>
<a href="index.html">Home</a></p>
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<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>Andrew W. Saul Interviews Vitamin D Expert<o:p></o:p></span></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:11.0pt;font-family:Arial;color:black'>MICHAEL F. HOLICK, MD,
PhD<o:p></o:p></span></b></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><b style='mso-bidi-font-weight:normal'><span
style='font-size:10.0pt;font-family:Arial;color:black'>“The population of the
world has been brainwashed by the American Academy of Dermatology and the
sunscreen industry, for 30 years, with the unrelenting message that you should
never be exposed to direct sunlight because it is going to cause serious skin
cancer and death.” <o:p></o:p></span></b></p>
<p class=MsoNormal><span style='font-size:10.0pt;font-family:Arial;
color:black'>(Michael Holick, MD)<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>Editor’s 2006 introduction: <i style='mso-bidi-font-style:normal'>Born
60 years ago in <st1:place w:st="on"><st1:City w:st="on">Jersey City</st1:City>,
<st1:State w:st="on">New Jersey</st1:State></st1:place>, Michael Holick
published his first scientific paper in 1970. Hundreds would follow, and now,
he is arguably the world’s leading authority on vitamin D. Yet Dr. Holick’s
advocacy of what he calls “sensible sun exposure” is so controversial that he
was fired from <st1:place w:st="on"><st1:PlaceName w:st="on">Boston</st1:PlaceName>
<st1:PlaceType w:st="on">University</st1:PlaceType> <st1:PlaceName w:st="on">Medical</st1:PlaceName>
<st1:PlaceType w:st="on">Center</st1:PlaceType></st1:place>’s dermatology
department. Controversy being no stranger to this Newsletter, we were pleased
when Dr. Holick agreed to an interview, which follows in edited form.<o:p></o:p></i></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DOCTOR YOURSELF NEWS: Dr. Holick, What are some of the
research-based benefits of more vitamin D?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DR. MICHAEL HOLICK: You can reduce cancer risk by 30 to 50% by
increasing vitamin D in the diet, or by sensible sun exposure. We gave mice
colon cancer, and followed them for 20 days. Tumor growth was markedly
reduced simply by having vitamin D in the diet. There was a 40% reduction in
tumor size. And, casual sun exposure actually decreases your risk of
melanoma. In <st1:country-region w:st="on"><st1:place w:st="on">Finland</st1:place></st1:country-region>,
back in the 1960’s, children that received 2,000 IU of vitamin D each day
reduced their risk of getting Type 1 diabetes by 80%. Every tissue and every
cell in your body has a receptor for vitamin D. Every tissue and every cell
of your body requires vitamin D to function properly.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Exactly how much vitamin D, and how much sun, do we
need?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Vitamin D deficiency is less than 400 IU per day along
with no sun exposure. If you take 400 IU daily, you would still have an
inadequate amount of vitamin D. Humans need 1,000 IU each day, or to be
exposed to sunlight. Five to ten minutes, arms and legs, three times a week,
is adequate.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: What is you opinion of the official US RDA/DRI
recommendations?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: I was on the committee that set them (National Academy
of Sciences, Panel on Calcium and Related Nutrients, 1996-1997). We have made
some progress in increasing the recommendations. They are now 200 IU/day for
children and adults up to age 50; 400 IU for adults over 50; and 600 IU/day
for adults over 70.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Would you have liked to have set the recommendations
higher? <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Yes. At the time, we were obligated to base our
recommendations on the published literature before 1997. Based on new
evidence, I think infants, up to one year of age, need 400 IU/day. <st1:country-region
w:st="on"><st1:place w:st="on">Canada</st1:place></st1:country-region>
recommends 400 IU already. Then, from age one, and all through adulthood, I’d
recommend 1,000 IU/day. Everyone needs 1,000 IU of vitamin D3 each day.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: And how are we doing?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: In <st1:City w:st="on"><st1:place w:st="on">Boston</st1:place></st1:City>,
50% of adolescent boys and girls are vitamin D deficient. 70% of moms and 80%
their babies are vitamin D deficient at birth. These infants have no vitamin
D stores, and the moms have none to give them.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: And that means rickets?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Rickets is only the tip of the vitamin D deficiency
iceberg. If you are vitamin D deficient in childhood, you are 2.4 times more
likely to develop Type 1 diabetes.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: And for people of color?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Skin pigment is a natural sunscreen. African American
children require two to three times as much sun exposure, without sunscreen,
to satisfy their requirement for vitamin D.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: What are the consequences of not getting enough
sunlight?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: If you live above 35 degrees north latitude, you are
twice as likely to develop multiple sclerosis. Living in higher latitudes
also means higher risk for Crohn's disease, rheumatoid arthritis, and high
blood pressure.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: What are some examples of “high latitude” cities?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Anything above <st1:place w:st="on"><st1:City w:st="on">Atlanta</st1:City>,
<st1:country-region w:st="on">Georgia</st1:country-region></st1:place>. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: I’ve been to <st1:City w:st="on"><st1:place w:st="on">Atlanta</st1:place></st1:City>.
To a Yankee like me, that’s pretty far south. Now you know I’m going to quote
you on this. . . <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: That’s fine. Anywhere above about 35 or 37 degrees
latitude, that is, anywhere north of <st1:place w:st="on"><st1:City w:st="on">Atlanta</st1:City>,
<st1:country-region w:st="on">Georgia</st1:country-region></st1:place>, you
basically cannot make vitamin D in your skin during the wintertime.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: And in the summer, should we tan?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: I do not believe in tanning.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: That seems a rather moderate position.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: I was fired from my position as Professor of Dermatology
at <st1:place w:st="on"><st1:PlaceName w:st="on">Boston</st1:PlaceName> <st1:PlaceType
w:st="on">University</st1:PlaceType> <st1:PlaceName w:st="on">Medical</st1:PlaceName>
<st1:PlaceType w:st="on">Center</st1:PlaceType></st1:place> because I have
been promoting sensible sun exposure, and had written the book, “The UV
Advantage.” I had held that position for nearly ten years.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Who fired you, and when? <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Dr. Barbara Gilchrest, BU <st1:place w:st="on"><st1:PlaceName
w:st="on">Medical</st1:PlaceName> <st1:PlaceType w:st="on">Center</st1:PlaceType></st1:place>
Chief of Dermatology, in February 2004. She and I remain personal friends.
I’m still full Professor of Medicine, Physiology, and Biophysics, and have
been for 20 years. Dr. Gilchrest has been quoted as saying that to suggest
that vitamin D deficiency is a significant health problem is “weak and
absurd.” She has also been quoted as saying that linking vitamin D deficiency
to medical illness is “schlock science.” I have never heard her rebut those
statements.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Were you fired entirely because of your stance on
vitamin D and for no other reason?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: No question about it. The <st1:place w:st="on"><st1:PlaceName
w:st="on">American</st1:PlaceName> <st1:PlaceType w:st="on">Academy</st1:PlaceType></st1:place>
of Dermatology is very uncomfortable about sensible sun exposure, and anyone
who recommends it. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: You’re telling us that the <st1:place w:st="on"><st1:PlaceName
w:st="on">American</st1:PlaceName> <st1:PlaceType w:st="on">Academy</st1:PlaceType></st1:place>
of Dermatology does not believe in sensible sun exposure?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: That is correct. They are believers in abstinence from
all sun exposure. They have been pretty firm about this. In May 2004, three
months after I was fired, I was asked to defend myself in front of all the
staff. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: How successful was it?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: I got people’s attention.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Who is most opposed to you?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: The “unenlightened” dermatologists of the <st1:place
w:st="on"><st1:PlaceName w:st="on">American</st1:PlaceName> <st1:PlaceType
w:st="on">Academy</st1:PlaceType></st1:place> of Dermatology.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Yet it seems to be particularly difficult to kill
yourself with vitamin D.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><span style='mso-spacerun:yes'> </span>HOLICK: True. One man
took 1,000,000 IU of vitamin D per day, orally, for six months. Of course, he
had the symptoms of severe vitamin D intoxication. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: But he lived to tell the tale?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Yes. His treatment was hydration (lots of water), and no
more vitamin D or sunshine for a while. He’s perfectly happy and healthy.
This was published in the New England Journal of Medicine. (Koutkia P, Chen
TC, Holick MF. Vitamin D intoxication associated with an over-the-counter
supplement. N Engl J Med. 2001 Jul 5;345(1):66-7.)<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: How many people have died from vitamin D or other
vitamins?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: I have no experience of anyone dying from vitamin
exposure. In thirty years, I’ve never seen it. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: And in the medical literature?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Not as far as I know.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: About how many people get too little vitamin D?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: In the <st1:country-region w:st="on">US</st1:country-region>
and <st1:country-region w:st="on"><st1:place w:st="on">Canada</st1:place></st1:country-region>,
about 50%. About one billion people, worldwide, are vitamin D deficient. This
is true even in sunny climates, because of lack of sun exposure.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: What advice do you wish to offer our readers?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: The most important thing is to increase your vitamin D
intake. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: What’s yours?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: I take 1,100 IU of vitamin D every day. <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Do you use sunblock?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: I do, but only after some sensible sun exposure.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: Do you wear a floppy hat? <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: Yes, after sensible sun exposure.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DY NEWS: You are one consistent person. So what’s the bottom
line?<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>HOLICK: The population of the world has been brainwashed by the <st1:place
w:st="on"><st1:PlaceName w:st="on">American</st1:PlaceName> <st1:PlaceType
w:st="on">Academy</st1:PlaceType></st1:place> of Dermatology and the
sunscreen industry, for 30 years, with the unrelenting message that you
should never be exposed to direct sunlight because it is going to cause
serious skin cancer and death. People are really quite surprised by the new
message that sensible sun exposure, in moderation, is very important for good
health. We should appreciate the sun for its benefits, and not abuse it.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>FOR FURTHER <st1:City w:st="on"><st1:place w:st="on">READING</st1:place></st1:City>:
<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>Holick, MF and Jenkins, M.<span style='mso-spacerun:yes'>
</span>The UV Advantage, iBooks: <st1:State w:st="on"><st1:place w:st="on">New
York</st1:place></st1:State>, 2004.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>Saul AW. Vitamin D: Deficiency, Diversity and Dosage. Journal of
Orthomolecular Medicine, 2003; Vol. 18, Numbers 3 and 4, p. 194-204. Posted
at <a href="http://www.doctoryourself.com/dvitamin.htm"><span
style='color:black'>http://www.doctoryourself.com/dvitamin.htm</span></a> <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>CANCER AND VITAMIN D<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>“A PubMed database search yielded 63 observational studies of
vitamin D status in relation to cancer risk, including 30 of colon, 13 of
breast, 26 of prostate, and 7 of ovarian cancer, and several that assessed
the association of vitamin D receptor genotype with cancer risk. The majority
of studies found a protective relationship between sufficient vitamin D
status and lower risk of cancer. The evidence suggests that efforts to
improve vitamin D status, for example by vitamin D supplementation, could
reduce cancer incidence and mortality at low cost, with few or no adverse
effects.” (<st1:City w:st="on">Garland</st1:City> CF, <st1:City w:st="on"><st1:place
w:st="on">Garland</st1:place></st1:City> FC, Gorham ED, Lipkin M, Newmark H,
Mohr SB, Holick MF. The role of vitamin D in cancer prevention. Am J Public
Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27.) <br>
<br>
”Inadequate photosynthesis or oral intake of Vitamin D are associated with
high incidence rates of colorectal cancer . . . Prompt public health action
is needed to increase intake of Vitamin D(3) to 1000IU/day, and to raise
25-hydroxyvitamin D by encouraging a modest duration of sunlight exposure.”
(Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL,
Giovannucci E, Wei M, Holick MF. Vitamin D and prevention of colorectal
cancer. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):179-94. Epub 2005 Oct
19.) <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>D DEFICIENCY IS WIDESPREAD<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>“Vitamin D inadequacy has been reported in approximately 36% of
otherwise healthy young adults and up to 57% of general medicine inpatients
in the <st1:country-region w:st="on">United States</st1:country-region>, and
in even higher percentages in <st1:place w:st="on">Europe</st1:place>. Recent
epidemiological data document the high prevalence of vitamin D inadequacy
among elderly patients . . . Supplemental doses of vitamin D and sensible sun
exposure could prevent deficiency in most of the general population.” (Holick
MF. High prevalence of vitamin D inadequacy and implications for health. Mayo
Clin Proc. 2006 Mar;81(3):353-73.) <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>DIABETES AND MULTIPLE SCLEROSIS<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial;
color:black'>”The conditions with strong evidence for a protective effect of
vitamin D include several bone diseases, muscle weakness, more than a dozen
types of internal cancers, multiple sclerosis, and type 1 diabetes mellitus.
. . The current vitamin D requirements in the <st1:country-region w:st="on"><st1:place
w:st="on">United States</st1:place></st1:country-region> are based on
protection against bone diseases. These guidelines are being revised upward
in light of new findings, especially for soft-tissue health.” (Grant WB,
Holick MF. Benefits and requirements of vitamin D for optimal health: a
review. Altern Med Rev. 2005 Jun;10(2):94-111.) <o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><o:p> </o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'>EXCELLENT
(AND FREE) VITAMIN D E-NEWSLETTER is yours for the asking available from John
Cannell and the Vitamin D Council: <a href="http://www.vitamindcouncil.com/">http://www.vitamindcouncil.com</a>
.<o:p></o:p></span></p>
<p class=MsoNormal><span style='font-size:11.0pt;font-family:Arial'><span
style='mso-tab-count:1'> </span></span><span style='font-size:
11.0pt'><o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>[You might also enjoy
reading <i>DOCTOR YOURSELF</i> (<a
href="http://www.doctoryourself.com/saulbooks.html">http://www.doctoryourself.com/saulbooks.html</a>)
and <i>FIRE YOUR DOCTOR!</i> (<a
href="http://www.doctoryourself.com/review.html">http://www.doctoryourself.com/review.html</a>)]
<o:p></o:p></span></p>
<p><span style='font-size:11.0pt;font-family:Arial'>Interview and comments
copyright 2006 and prior years by Andrew W. Saul.<o:p></o:p></span></p>
<p><span style='font-size:10.0pt;font-family:Arial'><span
style='mso-spacerun:yes'> </span><br>
</span><span style='font-size:11.0pt;font-family:Arial'> <o:p></o:p></span></p>
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style='text-decoration:none;text-underline:none'><img border=0 width=55
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